| Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition SG Sarafianos, B Marchand, K Das, DM Himmel, MA Parniak, SH Hughes, ... Journal of molecular biology 385 (3), 693-713, 2009 | 707 | 2009 |
| Crystal structure of HIV‐1 reverse transcriptase in complex with a polypurine tract RNA: DNA SG Sarafianos, K Das, C Tantillo, AD ClarkJr, J Ding, JM Whitcomb, ... The EMBO journal, 2001 | 533 | 2001 |
| Structure and functional implications of the polymerase active site region in a complex of HIV-1 RT with a double-stranded DNA template-primer and an antibody Fab fragment at 2 … J Ding, K Das, Y Hsiou, SG Sarafianos, AD Clark Jr, A Jacobo-Molina, ... Journal of molecular biology 284 (4), 1095-1111, 1998 | 421 | 1998 |
| Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with β-branched amino acids SG Sarafianos, K Das, AD Clark Jr, J Ding, PL Boyer, SH Hughes, ... Proceedings of the national academy of sciences 96 (18), 10027-10032, 1999 | 393 | 1999 |
| Molecular modeling and biochemical characterization reveal the mechanism of hepatitis B virus polymerase resistance to lamivudine (3TC) and emtricitabine (FTC) K Das, X Xiong, H Yang, CE Westland, CS Gibbs, SG Sarafianos, ... Journal of virology 75 (10), 4771-4779, 2001 | 348 | 2001 |
| Selective excision of AZTMP by drug-resistant human immunodeficiency virus reverse transcriptase PL Boyer, SG Sarafianos, E Arnold, SH Hughes Journal of virology 75 (10), 4832-4842, 2001 | 339 | 2001 |
| The RNA polymerase “switch region” is a target for inhibitors J Mukhopadhyay, K Das, S Ismail, D Koppstein, M Jang, B Hudson, ... Cell 135 (2), 295-307, 2008 | 275 | 2008 |
| Structures of HIV‐1 reverse transcriptase with pre‐and post‐translocation AZTMP‐terminated DNA SG Sarafianos, AD ClarkJr, K Das, S Tuske, JJ Birktoft, P Ilankumaran, ... The EMBO journal, 2002 | 260 | 2002 |
| Molecular model of SARS coronavirus polymerase: implications for biochemical functions and drug design X Xu, Y Liu, S Weiss, E Arnold, SG Sarafianos, J Ding Nucleic acids research 31 (24), 7117-7130, 2003 | 259 | 2003 |
| X-ray crystal structures of native HIV-1 capsid protein reveal conformational variability AT Gres, KA Kirby, VN KewalRamani, JJ Tanner, O Pornillos, ... Science 349 (6243), 99-103, 2015 | 257 | 2015 |
| Inhibition of bacterial RNA polymerase by streptolydigin: stabilization of a straight-bridge-helix active-center conformation S Tuske, SG Sarafianos, X Wang, B Hudson, E Sineva, J Mukhopadhyay, ... Cell 122 (4), 541-552, 2005 | 235 | 2005 |
| Novel inhibitors of severe acute respiratory syndrome coronavirus entry that act by three distinct mechanisms AO Adedeji, W Severson, C Jonsson, K Singh, SR Weiss, SG Sarafianos Journal of virology 87 (14), 8017-8028, 2013 | 231 | 2013 |
| Mechanism of nucleic acid unwinding by SARS-CoV helicase AO Adedeji, B Marchand, AJW Te Velthuis, EJ Snijder, S Weiss, RL Eoff, ... PloS one 7 (5), e36521, 2012 | 201 | 2012 |
| Structures of HIV-1 RT–DNA complexes before and after incorporation of the anti-AIDS drug tenofovir S Tuske, SG Sarafianos, AD Clark Jr, J Ding, LK Naeger, KL White, ... Nature structural & molecular biology 11 (5), 469-474, 2004 | 188 | 2004 |
| Capsid-CPSF6 interaction licenses nuclear HIV-1 trafficking to sites of viral DNA integration V Achuthan, JM Perreira, GA Sowd, M Puray-Chavez, WM McDougall, ... Cell Host & Microbe 24 (3), 392-404. e8, 2018 | 185 | 2018 |
| Role of methionine 184 of human immunodeficiency virus type-1 reverse transcriptase in the polymerase function and fidelity of DNA synthesis VN Pandey, N Kaushik, N Rege, SG Sarafianos, PNS Yadav, MJ Modak Biochemistry 35 (7), 2168-2179, 1996 | 183 | 1996 |
| The role of steric hindrance in 3TC resistance of human immunodeficiency virus type-1 reverse transcriptase HQ Gao, PL Boyer, SG Sarafianos, E Arnold, SH Hughes Journal of molecular biology 300 (2), 403-418, 2000 | 173 | 2000 |
| Taking aim at a moving target: designing drugs to inhibit drug-resistant HIV-1 reverse transcriptases SG Sarafianos, K Das, SH Hughes, E Arnold Current opinion in structural biology 14 (6), 716-730, 2004 | 172 | 2004 |
| Touching the heart of HIV-1 drug resistance: the fingers close down on the dNTP at the polymerase active site SG Sarafianos, K Dasi, J Dingi, PL Boyer, SH Hughes, E Arnold Chemistry & biology 6 (5), R137-R146, 1999 | 170 | 1999 |
| HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site DM Himmel, SG Sarafianos, S Dharmasena, MM Hossain, ... ACS chemical biology 1 (11), 702-712, 2006 | 169 | 2006 |
